info:eu-repo/semantics/article
Mutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis
Fecha
2019-12Registro en:
Morbidoni, Héctor Ricardo; de la Iglesia, Agustina Inés; Figueroa, Virginia; Di Capua, Cecilia Beatriz; Ioerger, Thomas R.; et al.; Mutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis; Microbiological Society Korea; Access Microbiology; 1; 10; 12-2019; 1-7
2516-8290
CONICET Digital
CONICET
Autor
Morbidoni, Héctor Ricardo
de la Iglesia, Agustina Inés
Figueroa, Virginia
Di Capua, Cecilia Beatriz
Ioerger, Thomas R.
Parish, Tanya
Resumen
Azole drugs such as econazole, are active on Mycobacterium tuberculosis and Mycobacterium smegmatis; however, the identification of their target(s) is still pending. It has been reported that mutations in the non-essential system mmpL5-mmpS5 conferred resistance to econazole in M. tuberculosis. We herein report that an azole-resistant mutant screen in M. smegmatis rendered mutations in rshA, encoding a non-essential anti-sigma H protein.