info:eu-repo/semantics/article
Carrageenans from Sarcothalia crispata and Gigartina skottsbergii: Structural Analysis and Interpolyelectrolyte Complex Formation for Drug Controlled Release
Fecha
2018-12Registro en:
Hughes, Melanie Hebe; Prado, Héctor Juan; Rodríguez, María Cecilia; Michetti, Karina Mariel; Leonardi, Patricia Ines; et al.; Carrageenans from Sarcothalia crispata and Gigartina skottsbergii: Structural Analysis and Interpolyelectrolyte Complex Formation for Drug Controlled Release; Springer; Marine Biotechnology; 20; 6; 12-2018; 706-717
1436-2228
CONICET Digital
CONICET
Autor
Hughes, Melanie Hebe
Prado, Héctor Juan
Rodríguez, María Cecilia
Michetti, Karina Mariel
Leonardi, Patricia Ines
Matulewicz, Maria Cristina
Resumen
The aims of the present study were to characterize for the first time the carrageenan extracted from cystocarpic stage of S. crispata collected in the Patagonian coast of Argentina, and to prepare interpolyelectrolytic complexes (IPECs) between the polysaccharide extracted from cystocarpic stage of Sarcothalia crispata and Gigartina skottsbergii thalli, and basic butylated methacrylate copolymer (Eudragit E), in order to test their potential for the controlled release of ibuprofen as model drug. The structural determination revealed that the polysaccharides extracted from S. crispata and G. skottsbergii were mainly constituted by κ-carrageenan, particularly in the case of G. skottsbergii; however, significant amounts of ι- and ν-carrageenan were also detected in both polygalactans. The differences in diad composition and possibly in their distribution along the polysaccharide chain of both carrageenans would favor a different arrangement in the resulting IPEC structure. The smaller pores observed by scanning electron microscopy in the IPEC of S. crispata suggest that the kinks in the polysaccharide backbone are evenly distributed, resulting in a slower ibuprofen release compared to the IPEC of G. skottsbergii.