Copper nanoparticles in click chemistry: an alternative catalytic system for the cycloaddition of terminal alkynes and azides

Abstract

Readily prepared copper nanoparticles have been found to effectively catalyse the 1,3-dipolar cycloaddition of a variety of azides and alkynes furnishing the corresponding 1,2,3-triazoles in excellent yields. Both the preparation of the nanoparticles and the click reaction proceed in short reaction times.