info:eu-repo/semantics/article
Structure-activity relationship of berberine and derivatives acting as antifungal compounds
Fecha
2006-06Registro en:
Enriz, Ricardo Daniel; Freile, Monica Liliana; Structure-activity relationship of berberine and derivatives acting as antifungal compounds; Asociación Química Argentina; Journal of the Argentine Chemical Society; 94; 1-3; 6-2006; 113-119
0365-0375
CONICET Digital
CONICET
Autor
Enriz, Ricardo Daniel
Freile, Monica Liliana
Resumen
A structure-activity relationship study of berberine and structurally related compounds is reported. Berberine, was chemically modified in order to obtain canadine and oxyberberine. The in vitro evaluation of antifungal activity of berberine, canadine, oxyberberine, liriodenine, o-methyl-mostachatoline and other four derivatives is also reported here. Our results allow us to determine the minimal structural requirements to produce the antifungal response and can provide a guide for the design of new compounds with these properties.