info:eu-repo/semantics/article
Changes in vascular function and autonomic balance during the first trimester of pregnancy and its relationship with the new-born weight
Fecha
2021-08Registro en:
Benbenuto, Silvia; Joo Turoni, Claudio Martín; Marañón, Rodrigo Oscar; Chahla, Rossana; Peral, Maria de Los Angeles; Changes in vascular function and autonomic balance during the first trimester of pregnancy and its relationship with the new-born weight; Informa Healthcare; Journal Of Obstetrics And Gynaecology; 8-2021; 1-22
0144-3615
CONICET Digital
CONICET
Autor
Benbenuto, Silvia
Joo Turoni, Claudio Martín
Marañón, Rodrigo Oscar
Chahla, Rossana
Peral, Maria de Los Angeles
Resumen
This study aimed to evaluate vascular function changes and autonomic balance during the first trimester of pregnancy and its relationship with the new-born weight. This prospective study performed in pregnant (PG) women and after delivery (not pregnant: NPG) evaluated the endothelial function (EF) and arterial stiffness (AS) by a non-invasive method. We evaluated the heart rate variability (HRV), parasympathetic nervous system (PNS), sympathetic nervous system (SNS) indexes by electrocardiogram (5 min) and the urinary nitrite excretion (NOx). PG increased EF and NOx and decreased AS and HRV. PG decreased the PNS index and augmented the SNS index. The new-born weight positively correlated with the PNS index (Pearson?s r: 0.4291; p<.05), NOx, HRV and negatively correlated with AS. In summary, in pregnancy, although haemodynamically, the SNS activation plays a compensatory role, the low rates of PNS inhibition are essential to ensure normal foetal growth.