info:eu-repo/semantics/article
Phylogeography and evolutionary history of hepatitis E virus genotype 3 in Argentina
Fecha
2022-01Registro en:
Pisano, María Belén; Culasso, Andrés Carlos Alberto; Altabert, Nancy; Martinez Wassaf, Maribel Graciela; Nates, Silvia Viviana; et al.; Phylogeography and evolutionary history of hepatitis E virus genotype 3 in Argentina; NLM (Medline); Transactions of the Royal Society of Tropical Medicine and Hygiene; 116; 1; 1-2022; 34-42
0035-9203
1878-3503
CONICET Digital
CONICET
Autor
Pisano, María Belén
Culasso, Andrés Carlos Alberto
Altabert, Nancy
Martinez Wassaf, Maribel Graciela
Nates, Silvia Viviana
González, Jorge Enrique
Contigiani de Minio, Marta Silvia
Campos, Rodolfo Hector
Ré, Viviana Elizabeth
Resumen
BACKGROUND: Few studies about the evolutionary history of the hepatitis E virus (HEV) have been conducted. The aim of our work was to investigate and make inferences about the origin and routes of dispersion of HEV-3 in Argentina. METHODS: Phylogenetic, coalescent and phylogeographic analyses were performed using a 322-bp ORF2 genomic fragment of all HEV-3 sequences with known date and place of isolation published at GenBank until May 2018 (n=926), including 16 Argentinian sequences (isolated from pigs, water and humans). RESULTS: Phylogenetic analysis revealed two clades within HEV-3: abchij and efg. All Argentinian samples were grouped intermingled within clade 3abchij. The coalescent analysis showed that the most recent common ancestor for the clade 3abchij would have existed around the year 1967 (95% highest posterior density (HPD): 1963-1970). The estimated substitution rate was 1.01×10-2 (95%HPD: 9.3×10-3-1.09×10-2) substitutions/site/y, comparable with the rate previously described. The phylogeographic approach revealed a correspondence between phylogeny and place of origin for Argentinian samples, suggesting many HEV introductions in the country, probably from Europe and Japan. CONCLUSIONS: This is the first evolutionary inference of HEV-3 that includes Argentinian strains, showing the circulation of many HEV-3 subtypes, obtained from different sources and places, with recent diversification processes. ACCESSION NUMBERS: [KX812460], [KX812461], [KX812462], [KX812465], [KX812466], [KX812467], [KX812468], [KX812469].