info:eu-repo/semantics/article
Is a constant low-entropy process at the root of glycolytic oscillations?
Fecha
2018-09Registro en:
Thoke, Henrik Seir; Olsen, Lars F.; Duelund, Lars; Stock, R. P.; Heimburg, Thomas; et al.; Is a constant low-entropy process at the root of glycolytic oscillations?; Springer; Journal Of Biological Physics; 44; 3; 9-2018; 419-431
0092-0606
1573-0689
CONICET Digital
CONICET
Autor
Thoke, Henrik Seir
Olsen, Lars F.
Duelund, Lars
Stock, R. P.
Heimburg, Thomas
Bagatolli, Luis Alberto
Resumen
We measured temporal oscillations in thermodynamic variables such as temperature, heat flux, and cellular volume in suspensions of non-dividing yeast cells which exhibit temporal glycolytic oscillations. Oscillations in these variables have the same frequency as oscillations in the activity of intracellular metabolites, suggesting strong coupling between them. These results can be interpreted in light of a recently proposed theoretical formalism in which isentropic thermodynamic systems can display coupled oscillations in all extensive and intensive variables, reminiscent of adiabatic waves. This interpretation suggests that oscillations may be a consequence of the requirement of living cells for a constant low-entropy state while simultaneously performing biochemical transformations, i.e., remaining metabolically active. This hypothesis, which is in line with the view of the cellular interior as a highly structured and near equilibrium system where energy inputs can be low and sustain regular oscillatory regimes, calls into question the notion that metabolic processes are essentially dissipative.