info:eu-repo/semantics/article
Induction of nitric oxide synthase activity in adrenal cells
Fecha
2000-12Registro en:
Cymeryng, Cora Betriz; Lotito, S.P.; Colonna, C.; Cornejo Maciel, Maria Fabiana; Podestá, E. J.; Induction of nitric oxide synthase activity in adrenal cells; Taylor & Francis; Endocrine Research; 26; 4; 12-2000; 589-595
0743-5800
CONICET Digital
CONICET
Autor
Cymeryng, Cora Betriz
Lotito, S.P.
Colonna, C.
Cornejo Maciel, Maria Fabiana
Podestá, E. J.
Resumen
The induction of nitric oxide synthase (NOS) II by bacterial lypopolysaccharide (LPS) was studied in a steroidogenic mouse tumor adrenal cell line (Y1). Conditioned media from LPS-stimulated peritoneal macrophages induced an increase in NOS II expression as shown by western and northern blot analysis. Accordingly, in the presence of conditioned media an increase in nitrite levels was observed. In addition, steroid production was significantly decreased. In conclusion, NOS II expression could be induced in steroidogenic cells with a concomitant inhibition of steroid production.