dc.creatorGalletti, Jeremías Gastón
dc.creatorde Paiva, Cintia S.
dc.date.accessioned2022-02-07T19:09:57Z
dc.date.accessioned2022-10-15T03:26:28Z
dc.date.available2022-02-07T19:09:57Z
dc.date.available2022-10-15T03:26:28Z
dc.date.created2022-02-07T19:09:57Z
dc.date.issued2021-04
dc.identifierGalletti, Jeremías Gastón; de Paiva, Cintia S.; The ocular surface immune system through the eyes of aging; Ethis Communicatins, Inc; Ocular Surface; 20; 4-2021; 139-162
dc.identifier1542-0124
dc.identifierhttp://hdl.handle.net/11336/151491
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4339936
dc.description.abstractSince the last century, advances in healthcare, housing, and education have led to an increase in life expectancy. Longevity is accompanied by a higher prevalence of age-related diseases, such as cancer, autoimmunity, diabetes, and infection, and part of this increase in disease incidence relates to the significant changes that aging brings about in the immune system. The eye is not spared by aging either, presenting with age-related disorders of its own, and interestingly, many of these diseases have immune pathophysiology. Being delicate organs that must be exposed to the environment in order to capture light, the eyes are endowed with a mucosal environment that protects them, the so-called ocular surface. As in other mucosal sites, immune responses at the ocular surface need to be swift and potent to eliminate threats but are at the same time tightly controlled to prevent excessive inflammation and bystander damage. This review will detail how aging affects the mucosal immune response of the ocular surface as a whole and how this process relates to the higher incidence of ocular surface disease in the elderly.
dc.languageeng
dc.publisherEthis Communicatins, Inc
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.jtos.2021.02.007
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1542012421000070
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectAGING
dc.subjectGOBLET CELLS
dc.subjectIMMUNE CELLS
dc.subjectLACRIMAL GLAND
dc.subjectT REGULATORY T CELLS
dc.subjectTEAR FILM
dc.titleThe ocular surface immune system through the eyes of aging
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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