info:eu-repo/semantics/article
ROS-generating rare-earth coordination networks for photodynamic inactivation of Candida albicans
Fecha
2021-03-31Registro en:
Godoy, Agustín Alejandro; Bernini, Maria Celeste; Funes, Matías Daniel; Sortino, Maximiliano Andrés; Collins, Sebastián Enrique; et al.; ROS-generating rare-earth coordination networks for photodynamic inactivation of Candida albicans; Royal Society of Chemistry; Dalton Transactions; 50; 17; 31-3-2021; 5853-5864
1477-9226
CONICET Digital
CONICET
Autor
Godoy, Agustín Alejandro
Bernini, Maria Celeste
Funes, Matías Daniel
Sortino, Maximiliano Andrés
Collins, Sebastián Enrique
Narda, Griselda Edith
Resumen
Water–ethanol suspensions of 2D coordination network (CN) based on rare earth elements and mixed ligands were evaluated as reactive oxygen species (ROS) generators under UV light irradiation, in contact with a biomimetic substrate (tryptophan) or an O2( 1 Δg) quencher (1,3-diphenylisobenzofuran; 1,3-DPBF). A combination of bottom-up and top-down strategies was implemented in order to obtain nano-sized CN particles and the subsequent colloidal suspensions were also tested towards photodynamic inactivation of Candida albicans (C. albicans). SEM, TEM, FTIR, and XRD techniques were applied to characterize the solids and ICP-AES was employed to determine the metal content of the colloidal suspensions. Promising results were found indicating that the presence of Tb3+ allows an intersystem crossing suitable for singlet oxygen generation, resulting in the antifungal activity of C. albicans culture upon UV-irradiation.