A Bioactive Trypanosoma cruzi Bromodomain Inhibitor from Chemically Engineered Extracts

dc.creatorRamallo, Ivana Ayelen
dc.creatorAlonso, Victoria Lucia
dc.creatorRúa, Federico
dc.creatorSerra, Esteban Carlos
dc.creatorFurlan, Ricardo Luis Eugenio
dc.date.accessioned2020-01-08T20:57:39Z
dc.date.accessioned2022-10-15T03:03:50Z
dc.date.available2020-01-08T20:57:39Z
dc.date.available2022-10-15T03:03:50Z
dc.date.created2020-01-08T20:57:39Z
dc.date.issued2018-04
dc.identifierRamallo, Ivana Ayelen; Alonso, Victoria Lucia; Rúa, Federico; Serra, Esteban Carlos; Furlan, Ricardo Luis Eugenio; A Bioactive Trypanosoma cruzi Bromodomain Inhibitor from Chemically Engineered Extracts; American Chemical Society; ACS Combinatorial Science; 20; 4; 4-2018; 220-228
dc.identifier2156-8944
dc.identifierhttp://hdl.handle.net/11336/94033
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4338008
dc.description.abstractA set of chemically engineered extracts enriched in compounds including N-N and N-O fragments in their structures was prepared. Bromodomain binding screening and bioguided fractionation led to the identification of one oxime hit that interacts with TcBDF3 with affinity in the submicromolar range and that shows interesting antiparasitic properties against the different life cycle stages of T. cruzi.
dc.languageeng
dc.publisherAmerican Chemical Society
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1021/acscombsci.7b00172
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/acscombsci.7b00172
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectbromodomain inhibitor
dc.subjectChagas disease
dc.subjectchemically engineered extracts
dc.subjectoxime
dc.titleA Bioactive Trypanosoma cruzi Bromodomain Inhibitor from Chemically Engineered Extracts
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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