info:eu-repo/semantics/article
A Bioactive Trypanosoma cruzi Bromodomain Inhibitor from Chemically Engineered Extracts
Fecha
2018-04Registro en:
Ramallo, Ivana Ayelen; Alonso, Victoria Lucia; Rúa, Federico; Serra, Esteban Carlos; Furlan, Ricardo Luis Eugenio; A Bioactive Trypanosoma cruzi Bromodomain Inhibitor from Chemically Engineered Extracts; American Chemical Society; ACS Combinatorial Science; 20; 4; 4-2018; 220-228
2156-8944
CONICET Digital
CONICET
Autor
Ramallo, Ivana Ayelen
Alonso, Victoria Lucia
Rúa, Federico
Serra, Esteban Carlos
Furlan, Ricardo Luis Eugenio
Resumen
A set of chemically engineered extracts enriched in compounds including N-N and N-O fragments in their structures was prepared. Bromodomain binding screening and bioguided fractionation led to the identification of one oxime hit that interacts with TcBDF3 with affinity in the submicromolar range and that shows interesting antiparasitic properties against the different life cycle stages of T. cruzi.