info:eu-repo/semantics/article
Palladium-Catalyzed Direct C-H Arylation of 3-(Methylsulfinyl)thiophenes
Fecha
2018-05Registro en:
Jiang, Hui; Bellomo Peraza, Ana Ines; Zhang, Mengnan; Carroll, Patrick J.; Manor, Brian C.; et al.; Palladium-Catalyzed Direct C-H Arylation of 3-(Methylsulfinyl)thiophenes; American Chemical Society; Organic Letters; 20; 9; 5-2018; 2522-2525
1523-7060
CONICET Digital
CONICET
Autor
Jiang, Hui
Bellomo Peraza, Ana Ines
Zhang, Mengnan
Carroll, Patrick J.
Manor, Brian C.
Jia, Tiezheng
Walsh, Patrick J.
Resumen
A palladium-catalyzed direct arylation of (3-thiophene)S(O)Me derivatives has been developed. This protocol is effective for the selective synthesis of 2-arylated and 2,5-diarylated sulfinylthiophene derivatives with as low as 0.5 mol % catalyst loading. Various functional groups are well tolerated. A method to install two different aryl groups on 3-(methylsulfinyl)thiophenes is also introduced.