A murine model of dengue virus infection in suckling C57BL/6 and BALB/c mice

dc.creatorByrne, Alana Brooke
dc.creatorGarcía, Ayelén G.
dc.creatorBrahamian, Jorge Martin
dc.creatorMauri, Aldana
dc.creatorFerretti, Adrián
dc.creatorPolack, Fernando Pedro
dc.creatorTalarico, Laura Beatriz
dc.date.accessioned2021-10-19T13:20:06Z
dc.date.accessioned2022-10-15T02:28:52Z
dc.date.available2021-10-19T13:20:06Z
dc.date.available2022-10-15T02:28:52Z
dc.date.created2021-10-19T13:20:06Z
dc.date.issued2020-12
dc.identifierByrne, Alana Brooke; García, Ayelén G.; Brahamian, Jorge Martin; Mauri, Aldana; Ferretti, Adrián; et al.; A murine model of dengue virus infection in suckling C57BL/6 and BALB/c mice; John Wiley & Sons Inc; Animal Models and Experimental Medicine; 12-2020; 1-11
dc.identifier2576-2095
dc.identifierhttp://hdl.handle.net/11336/144239
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4335172
dc.description.abstractDengue is a significant public health concern across tropical and subtropical regions worldwide, principally causing disease in children. Very young children are at increased risk of severe manifestations of dengue infection. The mechanism of dengue disease in this population is not fully understood. In this study, we present a murine model of dengue virus primary infection in suckling C57BL/6 and BALB/c mice in order to investigate disease pathogenesis. Three‐day‐old C57BL/6 mice intraperitoneally infected with DENV‐2 NGC were more susceptible to infection than BALB/c mice, showing increased liver enzymes, extended viremia, dissemination to organs and histological alterations in liver and small intestine. Furthermore, the immune response in DENV‐infected C57BL/6 mice exhibited a marked Th1 bias compared to BALB/c mice. These findings highlight the possibility of establishing an immunocompetent mouse model of DENV‐2 infection in suckling mice that reproduces certain signs of disease observed in humans and that could be used to further study age‐related mechanisms of dengue pathogenesis.
dc.languageeng
dc.publisherJohn Wiley & Sons Inc
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/ame2.12145
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/ame2.12145
dc.rightshttps://creativecommons.org/licenses/by-nc/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDENGUE
dc.subjectMOUSE MODEL
dc.subjectSUCKLING MICE
dc.titleA murine model of dengue virus infection in suckling C57BL/6 and BALB/c mice
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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