Multiple response optimization of heat shock process for separation of bovine serum albumin from plasma

dc.creatorGonzalez, Ulises Andres
dc.creatorMenendez, C.
dc.creatorSaitua, Hugo Alberto
dc.creatorTito Rigau, Javier
dc.date.accessioned2018-11-09T20:53:17Z
dc.date.accessioned2022-10-15T02:11:07Z
dc.date.available2018-11-09T20:53:17Z
dc.date.available2022-10-15T02:11:07Z
dc.date.created2018-11-09T20:53:17Z
dc.date.issued2017-08
dc.identifierGonzalez, Ulises Andres; Menendez, C.; Saitua, Hugo Alberto; Tito Rigau, Javier; Multiple response optimization of heat shock process for separation of bovine serum albumin from plasma; Taylor; Separation Science and Technology; 52; 12; 8-2017; 1992-2001
dc.identifier0149-6395
dc.identifierhttp://hdl.handle.net/11336/64162
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4333762
dc.description.abstractBovine serum albumin produced by heat shock from bovine plasma has been researched for the effects of sodium caprylate concentration [Cap], temperature (T), and pH on yield (Yield%) and purity (BSA%). Response surface methodology and desirability function approaches were applied to optimize its process. The best compromise solution was found with BSA% = 95.0 and Yield% = 28.5 for a [Cap] = 2 mM, T = 67.9°C, and pH = 5. A Monte Carlo simulation showed that it is possible to obtain excellent values for each individual response. However, a techno-economic feasibility study must be carried out to determine which one is the best option.
dc.languageeng
dc.publisherTaylor
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1080/01496395.2017.1304421
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/01496395.2017.1304421
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectBOVINE SERUM ALBUMIN
dc.subjectMULTIPLE RESPONSE OPTIMIZATION
dc.subjectRESPONSE SURFACE METHODOLOGY
dc.titleMultiple response optimization of heat shock process for separation of bovine serum albumin from plasma
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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