info:eu-repo/semantics/article
α4 integrins and sialyl Lewis x modulation in chronic chagas disease: Further evidence of persistent immune activation
Fecha
2001-02Registro en:
Laucella, Susana Adriana; Riarte, A.; Prado, Natalia Jorgelina; Zapata, J.; Segura, Elsa Leonor; α4 integrins and sialyl Lewis x modulation in chronic chagas disease: Further evidence of persistent immune activation; Wiley Blackwell Publishing, Inc; Scandinavian Journal Of Immunology; 53; 5; 2-2001; 514-519
0300-9475
CONICET Digital
CONICET
Autor
Laucella, Susana Adriana
Riarte, A.
Prado, Natalia Jorgelina
Zapata, J.
Segura, Elsa Leonor
Resumen
We have previously shown that titers of soluble platelet selectin (s-P-selectin) and soluble vascular cell adhesion molecule-1 (s-VCAM-1) were increased in sera of patients with chronic Trypanosoma cruzi infection. In this study, we analyzed the expression of CD49d-integrins, that bind to VCAM-1, and sialyl Lewis x (SLex), which binds selectins, in peripheral blood lymphocytes of 27 patients with Chagas' disease at different levels of disease severity. Patients with a mild form of Chagas' disease showed a lower number of CD49d+ cells, in comparison with those with severe chronic cardiopathy. Decreased levels of CD49d+ cells were detected in CD3- cell populations. Conversely, SLex expression was found to be decreased in patients with severe Chagas' disease. Levels of soluble platelet endothelial cell adhesion molecule-1 (s-PECAM-1) were significantly increased in the plasma of patients with severe Chagas' disease while unaltered levels of MCP-1 were recorded. These data show that VCAM-1 and P-Selectin ligands are differentially expressed during the chronic phase of the Trypanosoma cruzi infection. These findings also reinforce a role of the P-selectin/SLex adhesion pathway rather than very late antigen-4 (VLA-4)/VCAM-1, in the pathogenesis of Chagas' disease.