DNA and chromosome damage induced by bleomycin in mammalian cells: An update

dc.creatorBolzan, Alejandro Daniel
dc.creatorBianchi, Martha S.
dc.date.accessioned2020-01-20T20:58:52Z
dc.date.accessioned2022-10-15T02:03:33Z
dc.date.available2020-01-20T20:58:52Z
dc.date.available2022-10-15T02:03:33Z
dc.date.created2020-01-20T20:58:52Z
dc.date.issued2018-01
dc.identifierBolzan, Alejandro Daniel; Bianchi, Martha S.; DNA and chromosome damage induced by bleomycin in mammalian cells: An update; Elsevier Science; Mutation Research. Reviews In Mutation Research; 775; 1-2018; 51-62
dc.identifier1383-5742
dc.identifierhttp://hdl.handle.net/11336/95309
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4333169
dc.description.abstractBleomycin (BLM) is an antibiotic isolated from Streptomyces verticillus. It has radiomimetic actions on DNA thus it has been widely used in clinical chemotherapy for the treatment of different types of cancer, including head and neck tumors, lymphomas, squamous-cell carcinomas and germ-cell tumors. Because of this, the study of BLM genotoxicity is of practical interest. This antibiotic is an S-independent clastogen and an agent that generates free radicals and induces single- and double-strand breaks in DNA. In the present review, we will summarize our current knowledge concerning the DNA and chromosome damage induced by BLM in mammalian cells, with emphasis on new developments published since 1991.
dc.languageeng
dc.publisherElsevier Science
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1383574217301205
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.mrrev.2018.02.003
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectBLEOMYCIN
dc.subjectGENOTOXICITY
dc.subjectCHROMOSOMAL ABERRATIONS
dc.subjectDNA DAMAGE
dc.subjectTELOMERE
dc.titleDNA and chromosome damage induced by bleomycin in mammalian cells: An update
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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