dc.creatorPrato, Cecilia Arahi
dc.creatorCarabelli, Julieta
dc.creatorCampetella, Oscar Eduardo
dc.creatorTribulatti, María Virginia
dc.date.accessioned2021-09-20T12:14:38Z
dc.date.accessioned2022-10-15T01:54:15Z
dc.date.available2021-09-20T12:14:38Z
dc.date.available2022-10-15T01:54:15Z
dc.date.created2021-09-20T12:14:38Z
dc.date.issued2020-07
dc.identifierPrato, Cecilia Arahi; Carabelli, Julieta; Campetella, Oscar Eduardo; Tribulatti, María Virginia; Galectin-8 Enhances T cell Response by Promotion of Antigen Internalization and Processing; Cell Press; iScience; 23; 7; 7-2020; 1-26
dc.identifier2589-0042
dc.identifierhttp://hdl.handle.net/11336/140816
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4332331
dc.description.abstractGalectin-8 (Gal-8) is a mammalian lectin endowed with immunostimulatory ability. In the present work, we demonstrate that Gal-8-glycan interactions on the surface of antigen-presenting cells (APCs) promote antigen binding and internalization, independently from antigen nature. Both Gal-8 and antigen were together internalized and localized in early endosomes. Interestingly, antigen processing by APCs was also accelerated in the presence of Gal-8 as a separate mechanism, distinct from the increased antigen internalization. Moreover, APCs pulsed together with antigen and Gal-8 were able to activate cognate CD4+ T cells more efficiently than those pulsed with antigen alone. This enhanced antigen presentation was still evident in the absence of costimulatory signals and APCs-derived soluble mediators. Therefore, our results provide evidence for as yet unrecognized mechanism by which Gal-8 stimulates the elicitation of the immune response in a lectin-dependent manner, by inducing antigen uptake and processing upon lattice formation at APCs surface.
dc.languageeng
dc.publisherCell Press
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S2589004220304648
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.isci.2020.101278
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCELL BIOLOGY
dc.subjectIMMUNOLOGY
dc.subjectMOLECULAR BIOLOGY
dc.titleGalectin-8 Enhances T cell Response by Promotion of Antigen Internalization and Processing
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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