dc.creator | Prato, Cecilia Arahi | |
dc.creator | Carabelli, Julieta | |
dc.creator | Campetella, Oscar Eduardo | |
dc.creator | Tribulatti, María Virginia | |
dc.date.accessioned | 2021-09-20T12:14:38Z | |
dc.date.accessioned | 2022-10-15T01:54:15Z | |
dc.date.available | 2021-09-20T12:14:38Z | |
dc.date.available | 2022-10-15T01:54:15Z | |
dc.date.created | 2021-09-20T12:14:38Z | |
dc.date.issued | 2020-07 | |
dc.identifier | Prato, Cecilia Arahi; Carabelli, Julieta; Campetella, Oscar Eduardo; Tribulatti, María Virginia; Galectin-8 Enhances T cell Response by Promotion of Antigen Internalization and Processing; Cell Press; iScience; 23; 7; 7-2020; 1-26 | |
dc.identifier | 2589-0042 | |
dc.identifier | http://hdl.handle.net/11336/140816 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/4332331 | |
dc.description.abstract | Galectin-8 (Gal-8) is a mammalian lectin endowed with immunostimulatory ability. In the present work, we demonstrate that Gal-8-glycan interactions on the surface of antigen-presenting cells (APCs) promote antigen binding and internalization, independently from antigen nature. Both Gal-8 and antigen were together internalized and localized in early endosomes. Interestingly, antigen processing by APCs was also accelerated in the presence of Gal-8 as a separate mechanism, distinct from the increased antigen internalization. Moreover, APCs pulsed together with antigen and Gal-8 were able to activate cognate CD4+ T cells more efficiently than those pulsed with antigen alone. This enhanced antigen presentation was still evident in the absence of costimulatory signals and APCs-derived soluble mediators. Therefore, our results provide evidence for as yet unrecognized mechanism by which Gal-8 stimulates the elicitation of the immune response in a lectin-dependent manner, by inducing antigen uptake and processing upon lattice formation at APCs surface. | |
dc.language | eng | |
dc.publisher | Cell Press | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S2589004220304648 | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.isci.2020.101278 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | CELL BIOLOGY | |
dc.subject | IMMUNOLOGY | |
dc.subject | MOLECULAR BIOLOGY | |
dc.title | Galectin-8 Enhances T cell Response by Promotion of Antigen Internalization and Processing | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:ar-repo/semantics/artículo | |
dc.type | info:eu-repo/semantics/publishedVersion | |