info:eu-repo/semantics/article
Platelet TLR4 at the crossroads of thrombosis and the innate immune response
Fecha
2018-12-04Registro en:
Schattner, Mirta Ana; Platelet TLR4 at the crossroads of thrombosis and the innate immune response; Federation of American Societies for Experimental Biology; Journal of Leukocyte Biology; 105; 5; 4-12-2018; 873-880
0741-5400
CONICET Digital
CONICET
Autor
Schattner, Mirta Ana
Resumen
Platelet TLR-4 activation by pathogen- or damage-associated molecular pattern molecules triggers pro-thrombotic, proinflammatory, and pro-coagulant effector responses. Moreover, platelet TLR4 has a prominent role as a sensor of high lipopolysaccharide circulating levels during sepsis and in the clearance of pathogens mediated by neutrophils. This review presents evidence pointing to TLR4 as a bridge connecting thrombosis and innate immunity.