Neuroprotective effects of human umbilical cord mesenchymal stromal cells in an immunocompetent animal model of Parkinson's disease

dc.creatorMathieu, Patricia Andrea
dc.creatorRoca, Valeria Ines
dc.creatorGamba, Cecilia
dc.creatordel Pozo, Ana
dc.creatorPitossi, Fernando Juan
dc.date.accessioned2020-02-12T00:43:37Z
dc.date.accessioned2022-10-15T01:48:14Z
dc.date.available2020-02-12T00:43:37Z
dc.date.available2022-10-15T01:48:14Z
dc.date.created2020-02-12T00:43:37Z
dc.date.issued2012-05
dc.identifierMathieu, Patricia Andrea; Roca, Valeria Ines; Gamba, Cecilia; del Pozo, Ana; Pitossi, Fernando Juan; Neuroprotective effects of human umbilical cord mesenchymal stromal cells in an immunocompetent animal model of Parkinson's disease; Elsevier Science; Journal of Neuroimmunology; 246; 1-2; 5-2012; 43-50
dc.identifier0165-5728
dc.identifierhttp://hdl.handle.net/11336/97248
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4331753
dc.description.abstractMicroglial activation in the substantia nigra (SN) is a ubiquitous feature in PD which could mediate toxic effects. Human mesenchymal stromal cells (hMSCs) possess immunomodulatory properties. We evaluated whether the transplantation of hMSCs obtained from umbilical cord had a neuroprotective effect in a not-immunosuppressed rat Parkinson's disease (PD) model. Rats receiving hMSCs in the SN displayed significant preservation in the number of dopaminergic neurons in the SN at 21. days after lesion and an improved performance in behavioral tests compared to control rats. However, no differences in any inflammatory parameter tested were found. These results suggest that grafted hMSCs exert neuroprotection but not neuromodulatory effects on degenerating dopaminergic neurons.
dc.languageeng
dc.publisherElsevier Science
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.jneuroim.2012.03.004
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0165572812000689
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectMESENCHYMAL STROMAL CELLS
dc.subjectNEUROPROTECTION
dc.subjectPARKINSON'S DISEASE
dc.titleNeuroprotective effects of human umbilical cord mesenchymal stromal cells in an immunocompetent animal model of Parkinson's disease
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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