Role of allopregnanolone on cerebellar granule cells neurogenesis

dc.creatorKeller, Elizabeth Ana
dc.creatorZamparini, A.
dc.creatorBorodinsky, L.N.
dc.creatorGravielle, Maria Clara
dc.creatorFiszman, Monica Lidia
dc.date.accessioned2020-01-10T20:34:49Z
dc.date.accessioned2022-10-15T01:22:00Z
dc.date.available2020-01-10T20:34:49Z
dc.date.available2022-10-15T01:22:00Z
dc.date.created2020-01-10T20:34:49Z
dc.date.issued2004-10
dc.identifierKeller, Elizabeth Ana; Zamparini, A.; Borodinsky, L.N.; Gravielle, Maria Clara; Fiszman, Monica Lidia; Role of allopregnanolone on cerebellar granule cells neurogenesis; Elsevier; Developmental Brain Research; 153; 1; 10-2004; 13-17
dc.identifier0165-3806
dc.identifierhttp://hdl.handle.net/11336/94394
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4329372
dc.description.abstractThe role of allopregnanolone on immature cerebellar granule cells (CGC) proliferation was studied. Allopregnanolone (0.1–1 μM) increased [3H]thymidine incorporation and cell number determined by neuronal counting and by an MTT colorimetric assay. The effect of the neurosteroid was completely prevented by preincubation with 10 mM MgCl2, 10 μM nifedipine, 10 μM picrotoxin or by 50 μM bicuculine. We conclude that ALLO affects cerebellar neurogenesis by increasing calcium influx through voltage-gated calcium channels and GABAA receptors activation.
dc.languageeng
dc.publisherElsevier
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0165380604002329
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.devbrainres.2004.07.009
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectALLOPREGNANOLONE
dc.subjectCALCIUM
dc.subjectCEREBELLUM
dc.subjectGABA A RECEPTOR
dc.subjectNEUROGENESIS
dc.subjectPROLIFERATION
dc.titleRole of allopregnanolone on cerebellar granule cells neurogenesis
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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