info:eu-repo/semantics/article
SLPI in the perfusion solution helps to identify graft quality in kidney transplants
Fecha
2019-08Registro en:
Ambrosi, Nella Gabriela; Caro, Fiorella Yanina; Osella, Francisco; Alvarez, Leonardo Diaz; Sánchez, Francisco; et al.; SLPI in the perfusion solution helps to identify graft quality in kidney transplants; Future Medicine; Biomarkers In Medicine; 13; 11; 8-2019; 895-906
1752-0363
CONICET Digital
CONICET
Autor
Ambrosi, Nella Gabriela
Caro, Fiorella Yanina
Osella, Francisco
Alvarez, Leonardo Diaz
Sánchez, Francisco
Toniolo, Fernanda
Guerrieri, Diego
Incardona, Claudio
Casadei, Domingo
Chuluyan, Hector Eduardo
Resumen
Aim: It is important to find biomarkers that identify the graft quality in kidney transplantation. Results & methodology: The level of SLPI in the cold preservation solution was used as a marker to predict early kidney graft function after transplantation. Before transplantation, kidneys were washed and SLPI was measured in the discarded solution. A retrospective analysis showed that patients with delayed graft function or rejection episodes in post-trasplant, had higher SLPI concentrations in the perfusion solution than patients without delayed graft function or rejections. Furthermore, SLPI could discriminate between patients with better or worse estimated glomerular filtration rate among low-risk patients (kidney donor profile index <80). Discussion & conclusion: These results suggest that the SLPI concentration in the perfusion solutions could be a predictor of short-term organ function and a complement to the kidney donor profile index score.