info:eu-repo/semantics/article
Brain network organization and social executive performance in frontotemporal dementia
Fecha
2016-02Registro en:
Sedeño, Lucas; Couto, Juan Blas Marcos; García Cordero, Indira Ruth; Melloni, Margherita; Báez Buitrago, Sandra Jimena; et al.; Brain network organization and social executive performance in frontotemporal dementia; Cambridge University Press; Journal of the International Neuropsychological Society : Jins; 22; 2; 2-2016; 250-262
1355-6177
CONICET Digital
CONICET
Autor
Sedeño, Lucas
Couto, Juan Blas Marcos
García Cordero, Indira Ruth
Melloni, Margherita
Báez Buitrago, Sandra Jimena
Sepúlveda, Juan Pablo Morales
Fraiman Borrazás, Daniel Edmundo
Huepe, David
Hurtado, Esteban
Matallana, Diana
Kuljis, Rodrigo
Torralva, Teresa
Chialvo, Dante Renato
Sigman, Mariano
Piguet, Olivier
Manes, Facundo Francisco
Ibáñez Barassi, Agustín Mariano
Resumen
Objectives: Behavioral variant frontotemporal dementia (bvFTD) is characterized by early atrophy in the frontotemporoinsular regions. These regions overlap with networks that are engaged in social cognition-executive functions, two hallmarks deficits of bvFTD. We examine (i) whether Network Centrality (a graph theory metric that measures how important a node is in a brain network) in the frontotemporoinsular network is disrupted in bvFTD, and (ii) the level of involvement of this network in social-executive performance. Methods: Patients with probable bvFTD, healthy controls, and frontoinsular stroke patients underwent functional MRI resting-state recordings and completed social-executive behavioral measures. Results: Relative to the controls and the stroke group, the bvFTD patients presented decreased Network Centrality. In addition, this measure was associated with social cognition and executive functions. To test the specificity of these results for the Network Centrality of the frontotemporoinsular network, we assessed the main areas from six resting-state networks. No group differences or behavioral associations were found in these networks. Finally, Network Centrality and behavior distinguished bvFTD patients from the other groups with a high classification rate. Conclusions: bvFTD selectively affects Network Centrality in the frontotemporoinsular network, which is associated with high-level social and executive profile.