info:eu-repo/semantics/article
Cyclooxygenase-2 in testes of infertile men: Evidence for the induction of prostaglandin synthesis by interleukin-1β
Fecha
2010-10Registro en:
Matzkin, Maria Eugenia; Mayerhofer, Artur; Rossi, Soledad Paola; Gonzalez, Betina; Gonzalez, Candela Rocio; et al.; Cyclooxygenase-2 in testes of infertile men: Evidence for the induction of prostaglandin synthesis by interleukin-1β; Elsevier Science Inc; Fertility and Sterility; 94; 5; 10-2010; 1933-1936
0015-0282
CONICET Digital
CONICET
Autor
Matzkin, Maria Eugenia
Mayerhofer, Artur
Rossi, Soledad Paola
Gonzalez, Betina
Gonzalez, Candela Rocio
Gonzalez de Calvar, Silvia Ines
Terradas, Claudio
Ponzio, Roberto Oscar
Puigdomenech, Elisa
Levalle, Oscar
Calandra, Ricardo Saul
Frungieri, Monica Beatriz
Resumen
As we previously reported, testes of men suffering from hypospermatogenesis and germ cell arrest or Sertoli cell-only syndrome show a major increase in the number of macrophages expressing interleukin-1β (IL-1β) and abundant expression of cyclooxygenase-2 (COX-2), the inducible isoform of the key enzyme in the biosynthesis of prostaglandins (PGs), in Leydig cells. In the present study we report [1] a positive correlation between IL-1β levels and COX-2 expression in testes of infertile patients, [2] the induction of COX-2 by IL-1β in mouse Leydig cells (TM3) and human macrophages (THP-1), and therefore [3] evidence for an IL-1β-dependent induction of testicular inflammatory states.