info:eu-repo/semantics/article
Two crystal forms of a helix-rich fatty acid- and retinol-binding protein, Na-FAR-1, from the parasitic nematode Necator americanus
Fecha
2012-07Registro en:
Gabrielsen, Mads; Rey, María Florencia; Griffiths, Kate; Roe, Andrew J.; Cooper, Alan; et al.; Two crystal forms of a helix-rich fatty acid- and retinol-binding protein, Na-FAR-1, from the parasitic nematode Necator americanus; Wiley Blackwell Publishing, Inc; Acta Crystallographica Section F-structural Biology And Crystallization Communications; 68; 7; 7-2012; 835-838
1744-3091
CONICET Digital
CONICET
Autor
Gabrielsen, Mads
Rey, María Florencia
Griffiths, Kate
Roe, Andrew J.
Cooper, Alan
Smith, Brian O.
Kennedy, Malcolm W.
Córsico, Betina
Resumen
Na-FAR-1 is an unusual -helix-rich fatty acid- and retinol-binding protein from Necator americanus, a blood-feeding intestinal parasitic nematode of humans. It belongs to the FAR protein family, which is unique to nematodes; no structural information is available to date for FAR proteins from parasites. Crystals were obtained with two different morphologies that corresponded to different space groups. Crystal form 1 exhibited space group P432 (unit-cell parameters a = b = c = 120.80 Å, α = β = γ = 90°) and diffracted to 2.5 Å resolution, whereas crystal form 2 exhibited space group F23 (unit-cell parameters a = b = c = 240.38 Å, α = β = γ = 90°) and diffracted to 3.2 Å resolution. Crystal form 2 showed signs of significant twinning.