info:eu-repo/semantics/article
Sexual dimorphism of neuroendocrine-immune interactions
Fecha
2002-12Registro en:
Spinedi, Nahuel; Gaillard, Rolf C.; Chisari, Andrea Nancy; Sexual dimorphism of neuroendocrine-immune interactions; Karger; Frontiers in Hormone Research; 29; 12-2002; 91-107
0301-3073
CONICET Digital
CONICET
Autor
Spinedi, Nahuel
Gaillard, Rolf C.
Chisari, Andrea Nancy
Resumen
In the bidirectional interplay between the immune and endocrine systems, the communications most deeply investigated up to now have been those between the immuhC:and the hypothalamo-pituita~y-adrenal (HPA) and the HP-gonadal (HPG) [for review see, axes. For instance, mitogen/antigen-activated immune cells secrete cytokines; in turn, these substances are able to stimulate the hypothalamus thus inducing the activation of the corticotropin-releasing hormone (CRR)-ergic function . Once the eRR neuronal system has been activated, this peptide is able to locally (centrally) inhibit the HPG axis function [for references see, and, via the corticotrope cells, to stimulate HPA axis function . Evidence indicates that gonadal steroids modulate immunological function . Our findings and those of other researchers suggest that while estrogens enhance the immune response , androgens inhibit it and that gonadectomyalters this response.