Photodynamic inactivation of multiresistant bacteria (KPC) using zinc(II)phthalocyanines

dc.creatorMiretti, Mariana
dc.creatorClementi, Romina
dc.creatorTempesti, Tomas Cristian
dc.creatorBaumgartner, Maria Teresa del V.
dc.date.accessioned2018-11-13T18:48:37Z
dc.date.accessioned2022-10-15T00:52:08Z
dc.date.available2018-11-13T18:48:37Z
dc.date.available2022-10-15T00:52:08Z
dc.date.created2018-11-13T18:48:37Z
dc.date.issued2017-09
dc.identifierMiretti, Mariana; Clementi, Romina; Tempesti, Tomas Cristian; Baumgartner, Maria Teresa del V.; Photodynamic inactivation of multiresistant bacteria (KPC) using zinc(II)phthalocyanines; Elsevier; Biorganic and Medicinal Chemistry Letters; 27; 18; 9-2017; 4341-4344
dc.identifier0960-894X
dc.identifierhttp://hdl.handle.net/11336/64374
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4326891
dc.description.abstractThe worldwide increase in antibiotic resistance has led to search of alternatives anti-microbial therapies such as photodynamic inactivation. The aim of this paper was to evaluate the photodynamic activity in vitro of a neutral and two cationic Zn phthalocyanines. Their photokilling activity was tested on Escherichia coli ATCC 25922 and Klebsiella pneumoniae Carbapenemase (KPC)-producing. After treating bacteria with phthalocyanines, the cultures were irradiated with white light. As a result, the bacteria were inactivated in presence of cationic phthalocyanines. The photoinactivation was dependent of the irradiation time and phthalocyanine concentration. The most effective photosensitizer on KPC-producing was Zinc(II)tetramethyltetrapyridino[2,3-b:2′,3′-g:2″,3″-l:2‴,3‴-q]porphyrazinium methylsulfate (ZnTM2,3PyPz). After irradiation using the water soluble ZnTM2,3PyPz (3 μM) the viability of KPC (30 min of irradiation) and E. coli (10 min of irradiation) decreased ≈99.995%.
dc.languageeng
dc.publisherElsevier
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.bmcl.2017.08.028
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0960894X17308296
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectE. COLI
dc.subjectK. PNEUMONIAE
dc.subjectMULTIRESISTANT BACTERIA
dc.subjectPHOTODYNAMIC INACTIVATION
dc.subjectZN PHTHALOCYANINE
dc.titlePhotodynamic inactivation of multiresistant bacteria (KPC) using zinc(II)phthalocyanines
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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