info:eu-repo/semantics/article
Photodynamic inactivation of multiresistant bacteria (KPC) using zinc(II)phthalocyanines
Fecha
2017-09Registro en:
Miretti, Mariana; Clementi, Romina; Tempesti, Tomas Cristian; Baumgartner, Maria Teresa del V.; Photodynamic inactivation of multiresistant bacteria (KPC) using zinc(II)phthalocyanines; Elsevier; Biorganic and Medicinal Chemistry Letters; 27; 18; 9-2017; 4341-4344
0960-894X
CONICET Digital
CONICET
Autor
Miretti, Mariana
Clementi, Romina
Tempesti, Tomas Cristian
Baumgartner, Maria Teresa del V.
Resumen
The worldwide increase in antibiotic resistance has led to search of alternatives anti-microbial therapies such as photodynamic inactivation. The aim of this paper was to evaluate the photodynamic activity in vitro of a neutral and two cationic Zn phthalocyanines. Their photokilling activity was tested on Escherichia coli ATCC 25922 and Klebsiella pneumoniae Carbapenemase (KPC)-producing. After treating bacteria with phthalocyanines, the cultures were irradiated with white light. As a result, the bacteria were inactivated in presence of cationic phthalocyanines. The photoinactivation was dependent of the irradiation time and phthalocyanine concentration. The most effective photosensitizer on KPC-producing was Zinc(II)tetramethyltetrapyridino[2,3-b:2′,3′-g:2″,3″-l:2‴,3‴-q]porphyrazinium methylsulfate (ZnTM2,3PyPz). After irradiation using the water soluble ZnTM2,3PyPz (3 μM) the viability of KPC (30 min of irradiation) and E. coli (10 min of irradiation) decreased ≈99.995%.