info:eu-repo/semantics/article
Synthesis and in vitro antiproliferative activities of (5-aryl-1,2,4-oxadiazole-3-yl) methyl D-ribofuranosides
Fecha
2017-07Registro en:
Avanzo, Romina Edith; Padrón, José Manuel; D'accorso, Norma Beatriz; Fascio, Mirta Liliana; Synthesis and in vitro antiproliferative activities of (5-aryl-1,2,4-oxadiazole-3-yl) methyl D-ribofuranosides; Pergamon-Elsevier Science Ltd; Biorganic and Medicinal Chemistry Letters; 27; 16; 7-2017; 3674-3677
0960-894X
CONICET Digital
CONICET
Autor
Avanzo, Romina Edith
Padrón, José Manuel
D'accorso, Norma Beatriz
Fascio, Mirta Liliana
Resumen
The emergence of multidrug resistance cell lines is one of the major obstacles in the success of cancer chemotherapeutic treatment. Therefore, it remains a big challenge the development of new and effective drugs to defeat cancer. The presence of nitrogen heterocycles in the architectural design of drugs has led to the discovery of new leading compounds. Herein, we report the synthesis, characterization and in vitro antiproliferative activity against six cancer cell lines of D-ribofuranoside derivatives bearing a 1,2,4-oxadiazolic ring, with the aim of developing new active compounds. Most of these derivatives exhibit significant antiproliferative activities in the micromolar range. Noteworthy, the most potent compound of the series showed better selectivity towards the more resistant colon cancer cell line WiDr.