info:eu-repo/semantics/article
Combined use of ivermectin and triclabendazole in sheep: In vitro and in vivo characterisation of their pharmacological interaction
Fecha
2009-11Registro en:
Lifschitz, Adrian Luis; Virkel, Guillermo Leon; Ballent, Mariana; Sallovitz, Juan Manuel; Lanusse, Carlos Edmundo; Combined use of ivermectin and triclabendazole in sheep: In vitro and in vivo characterisation of their pharmacological interaction; Elsevier; The Veterinary Journal; 182; 2; 11-2009; 261-268
1090-0233
CONICET Digital
CONICET
Autor
Lifschitz, Adrian Luis
Virkel, Guillermo Leon
Ballent, Mariana
Sallovitz, Juan Manuel
Lanusse, Carlos Edmundo
Resumen
This study evaluated the pharmacokinetic properties of ivermectin (IVM) and triclabendazole (TCBZ) given either separately or co-administered to sheep. Corriedale sheep received IVM alone, TCBZ alone or a combination of IVM and TCBZ intravenously. Ivermectin elimination was delayed and its plasma availability was 3-fold higher when co-administered with TCBZ. Similarly, plasma concentrations of TCBZ and its metabolites were influenced by the co-administration of IVM. Higher peak plasma concentrations of TCBZ metabolites were detected after the co-administration of TCBZ and IVM compared to those obtained following TCBZ treatment in isolation. Complementary in vitro assays were carried out to assess the influence of TCBZ on the P-glycoprotein-mediated intestinal transport of IVM, using the everted gut sac technique. Enhanced accumulation of IVM in the intestinal wall occurred after co-incubation with TCBZ.