info:eu-repo/semantics/article
Tucumanin, a β-hydroxy-γ-lactone bistetrahydrofuranic acetogenin from Annona cherimolia, is a potent inhibitor of mitochondrial complex I
Fecha
2004-09Registro en:
Barrachina, Isabel; Neske, Adriana; Granell, Susana; Bermejo, Almudena; Chahboune, Nadia; et al.; Tucumanin, a β-hydroxy-γ-lactone bistetrahydrofuranic acetogenin from Annona cherimolia, is a potent inhibitor of mitochondrial complex I; Georg Thieme Verlag Kg; Planta Medica; 70; 9; 9-2004; 866-868
0032-0943
CONICET Digital
CONICET
Autor
Barrachina, Isabel
Neske, Adriana
Granell, Susana
Bermejo, Almudena
Chahboune, Nadia
El Aouad, Noureddine
Alvarez, Olga
Bardon, Alicia del Valle
Zafra Polo, M. Carmen
Resumen
A new β-hydroxy-γ-methyl-γ-lactone bistetrahydrofuranic acetogenin, tucumanin, with the infrequent symmetrical threo/trans/threo/trans/ threo relative configuration at the tetrahydrofuran rings was isolated from Annona cherimolia (Annonaceae) seeds. The inhibitory potency on the mitochondrial complex I of acetogenins with this relative configuration (tucumanin and asimicin) was compared with that shown by the corresponding pairs with an asymmetrical threo/trans/threo/trans/erythro relative configuration (laherradurin/rolliniastatin-2, and itrabin/molvizarin). All these compounds act as selective inhibitors of mitochondrial complex 1 in the 0.18 - 1.55 nM range.