info:eu-repo/semantics/article
Acute-Phase Levels of CXCL8 as Risk Factor for Chronic Arthralgia Following Chikungunya Virus Infection
Fecha
2021-10Registro en:
Jacob Nascimento, Leile Camila; Carvalho, Caroline Xavier; Oliveira Silva, Monaíse Madalena; Kikuti, Mariana; Oliveira Anjos, Rosângela; et al.; Acute-Phase Levels of CXCL8 as Risk Factor for Chronic Arthralgia Following Chikungunya Virus Infection; Frontiers Media; Frontiers in Immunology; 12; 10-2021; 1-10
1664-3224
CONICET Digital
CONICET
Autor
Jacob Nascimento, Leile Camila
Carvalho, Caroline Xavier
Oliveira Silva, Monaíse Madalena
Kikuti, Mariana
Oliveira Anjos, Rosângela
Rodrigues Barbosa Fradico, Jordana
Campi Azevedo, Ana Carolina
Tauro, Laura Beatriz
Soares Campos, Gúbio
Sousa dos Santos Moreira, Patricia
Machado Portilho, Moyra
Assis Martins Filho, Olindo
Sousa Ribeiro, Guilherme
Galvão Reis, Mitermayer
Resumen
The immunopathogenesis of chikungunya virus (CHIKV) infection and the role of acute-phase immune response on joint pain persistence is not fully understood. We investigated the profile of serum chemokine and cytokine in CHIKV-infected patients with acute disease, compared the levels of these biomarkers to those of patients with other acute febrile diseases (OAFD) and healthy controls (HC), and evaluated their role as predictors of chronic arthralgia development. Chemokines and cytokines were measured by flow Cytometric Bead Array. Patients with CHIKV infection were further categorized according to duration of arthralgia (≤ 3 months vs >3 months), presence of anti-CHIKV IgM at acute-phase sample, and number of days of symptoms at sample collection (1 vs 2-3 vs ≥4). Patients with acute CHIKV infection had significantly higher levels of CXCL8, CCL2, CXCL9, CCL5, CXCL10, IL-1β, IL-6, IL-12, and IL-10 as compared to HC. CCL2, CCL5, and CXCL10 levels were also significantly higher in patients with CHIKV infection compared to patients with OAFD. Patients whose arthralgia lasted > 3 months had increased CXCL8 levels compared to patients whose arthralgia did not (p<0.05). Multivariable analyses further indicated that high levels of CXCL8 and female sex were associated with arthralgia lasting >3 months. Patients with chikungunya and OAFD had similar cytokine kinetics for IL-1β, IL-12, TNF, IFN-γ, IL-2, and IL-4, although the levels were lower for CHIKV patients. This study suggests that chemokines may have an important role in the immunopathogenesis of chronic chikungunya-related arthralgia.