Neuroprotective activity of a new erythropoietin formulation with increased penetration in the central nervous system

dc.creatorEtcheverrigaray, Marina
dc.creatorCeaglio, Natalia Analia
dc.creatorMattio, Mónica Cristina
dc.creatorRoggero, Marcos Enrique
dc.creatorAmadeo, Ignacio
dc.creatorForno, Angela Guillermina
dc.creatorPerotti, Norma Maria
dc.creatorKratje, Ricardo Bertoldo
dc.date.accessioned2020-02-02T21:18:41Z
dc.date.accessioned2022-10-14T23:22:57Z
dc.date.available2020-02-02T21:18:41Z
dc.date.available2022-10-14T23:22:57Z
dc.date.created2020-02-02T21:18:41Z
dc.date.issued2011-11
dc.identifierEtcheverrigaray, Marina; Ceaglio, Natalia Analia; Mattio, Mónica Cristina; Roggero, Marcos Enrique; Amadeo, Ignacio; et al.; Neuroprotective activity of a new erythropoietin formulation with increased penetration in the central nervous system; Biomed central; BMC Proceedings; 5; 11-2011; 1-3
dc.identifier1753-6561
dc.identifierhttp://hdl.handle.net/11336/96498
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4319002
dc.description.abstractApart from its hematopoietic effect, erythropoietin (EPO) is a molecule with high neuroprotective potential. However, its prolonged application may cause serious adverse effects due to the erythropoiesis stimulation. Therefore, an EPO derivative with neuroprotective properties but low hematopoietic activity, designated as neuropoietin (rhNEPO), was developed in our lab using an alternative purification process of the recombinant human erythropoietic counterpart (rhEPO) produced in CHO cells [1]. The in vitro cytoprotective activity of rhNEPO on neural phenotype cells and its brain uptake from blood are herein analyzed.
dc.languageeng
dc.publisherBiomed central
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.biomedcentral.com/content/pdf/1753-6561-5-S8-P3.pdf
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1186/1753-6561-5-S8-P3
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectERYTHROPOIETIN
dc.subjectCYTOPROTECTION
dc.subjectAPOPTOSIS
dc.titleNeuroprotective activity of a new erythropoietin formulation with increased penetration in the central nervous system
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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