info:eu-repo/semantics/article
α-MSH and γ-MSH modulate early release of hypothalamic PGE2 and NO induced by IL-1β differently
Fecha
2006-12Registro en:
Cragnolini, Andrea Beatriz; Caruso, Carla Mariana; Lasaga, Mercedes Isabel; Scimonelli, Teresa Nieves; α-MSH and γ-MSH modulate early release of hypothalamic PGE2 and NO induced by IL-1β differently; Elsevier Ireland; Neuroscience Letters; 409; 3; 12-2006; 168-172
0304-3940
CONICET Digital
CONICET
Autor
Cragnolini, Andrea Beatriz
Caruso, Carla Mariana
Lasaga, Mercedes Isabel
Scimonelli, Teresa Nieves
Resumen
Interleukin-1beta (IL-1beta) stimulates corticotropin-releasing hormone (CRH) secretion in hypothalamus, which involves the release of prostaglandins (PGE2) and nitric oxide (NO). We have demonstrated that melanocortins can inhibit the early effects of IL-1beta on the HPA axis by acting on the central nervous system (CNS). Our study investigated whether alpha-melanocyte stimulating hormone (alpha-MSH) and gamma-MSH could inhibit IL-1beta-induced PGE2 and NO release in hypothalamus in the rapid activation of the HPA axis. An i.c.v. injection of 12.5 ng/microl of IL-1beta significantly increased the release of PGE2 and NOS activity in the hypothalamus. Treatment with alpha-MSH (0.1 microg/microl) inhibited the effect of IL-1beta on PGE2 release. Also, gamma-MSH (1 microg/microl) eliminated the increase in NOS activity induced by IL-1beta. Our data indicate the modulatory role of melanocortins in the early hypothalamic response to IL-1beta, with different regulation of PGE2 and NO release.