info:eu-repo/semantics/article
Caged amino acids for visible-light photodelivery
Fecha
2008-03Registro en:
Salierno, Marcelo Javier; Fameli, Cecilia Irene; Etchenique, Roberto Argentino; Caged amino acids for visible-light photodelivery; Wiley VCH Verlag; European Journal of Inorganic Chemistry; 7; 3-2008; 1125-1128
1434-1948
CONICET Digital
CONICET
Autor
Salierno, Marcelo Javier
Fameli, Cecilia Irene
Etchenique, Roberto Argentino
Resumen
We present a photocleavable protecting group based on ruthenium bipyridyl complexes and suitable for amino acid photodelivery. We discuss the photochemical properties of the caged glutamate, which is a major neurotransmitter in the CNS. The molar absorptivity for the caged glutamate at 450 nm is ε = 4200 M-1cm-1 and its quantum yield of photore-lease at 450 nm is ΦPD = 0.035, which is about 17 times higher than that of the most active organic caged compound at this wavelength. Similar figures are obtained for other α-amino acids.