info:eu-repo/semantics/article
Antigenic and immunogenic spectrum of foot and mouth disease vaccine strain O1 Campos against representative viruses of topotypes that circulated in Asia over the past decade
Fecha
2017-04Registro en:
Galdo Novo, Sabrina; Malirat, Viviana; Maradei, Eduardo D.; Espinoza, Ana María; Smitsaart, Eliana; et al.; Antigenic and immunogenic spectrum of foot and mouth disease vaccine strain O1 Campos against representative viruses of topotypes that circulated in Asia over the past decade; Elsevier; Vaccine; 35; 18; 4-2017; 2303-2307
0264-410X
CONICET Digital
CONICET
Autor
Galdo Novo, Sabrina
Malirat, Viviana
Maradei, Eduardo D.
Espinoza, Ana María
Smitsaart, Eliana
Pedemonte, Andrea
Mattion, Nora Marta
Bergmann, Ingrid Evelyn
Resumen
Identifying vaccine strains to control outbreaks of foot-and-mouth disease virus that could spread to new regions is essential for contingency plans. This is the first report on the antigenic/immunogenic relationships of the South American O1/Campos vaccine strain with representative isolates of the three currently active Asian type O topotypes. Virus neutralization tests using O1/Campos post-vaccination sera derived from cattle and pigs predicted for both species acceptable cross-protection, even after single vaccination, established by r1 values and by expectancy of protection using monovalent or polyvalent vaccines. The results indicate that effective oil vaccines containing the O1/Campos strain can be used against Asian isolates, expanding the scope of O1/Campos strain included in vaccine banks to control emergencies caused by Asian viruses, even on single-dose vaccination, and to cover the need of effective vaccines in Asia during systematic vaccination.