info:eu-repo/semantics/article
Synthesis and anticonvulsant activity of amino acid-derived sulfamides
Fecha
2009-03Registro en:
Gavernet, Luciana; Elvira, Juan E.; Samaja, Gisela Anabel; Pastore, Valentina; Cravero, Mariana Sella; et al.; Synthesis and anticonvulsant activity of amino acid-derived sulfamides; American Chemical Society; Journal of Medicinal Chemistry; 52; 6; 3-2009; 1592-1601
0022-2623
CONICET Digital
CONICET
Autor
Gavernet, Luciana
Elvira, Juan E.
Samaja, Gisela Anabel
Pastore, Valentina
Cravero, Mariana Sella
Enrique, Andrea Verónica
Estiu, Guillermina Lucia
Bruno Blanch, Luis Enrique
Resumen
Sulfamides are promising functions for the design of new antiepileptic drugs (Bioorg. Med. Chem. 2007, 15, 1556-1567; 5604-5614). Following previous research in this line, a set of amino acid-derived sulfamides has been designed, synthesized, and tested as new anticonvulsant compounds. The experimental data confirmed the ability of some of the structures to suppress the convulsions originated by the electrical seizure (MES test) at low doses (100 mg/kg).