info:eu-repo/semantics/article
One-pot sequential synthesis and antifungal activity of 2-(benzylsulfonyl)benzothiazole derivatives
Fecha
2019-09Registro en:
Ballari, María Sol; Herrera Cano, Natividad Carolina; Wunderlin, Daniel Alberto; Feresin, Gabriela Egly; Santiago, Ana Noemi; One-pot sequential synthesis and antifungal activity of 2-(benzylsulfonyl)benzothiazole derivatives; Royal Society of Chemistry; RSC Advances; 9; 50; 9-2019; 29405-29413
2046-2069
CONICET Digital
CONICET
Autor
Ballari, María Sol
Herrera Cano, Natividad Carolina
Wunderlin, Daniel Alberto
Feresin, Gabriela Egly
Santiago, Ana Noemi
Resumen
New antifungal agrochemicals, derived from 2-(benzylsulfonyl)benzothiazole were synthesized by an environmentally friendly method, using water as reaction medium. These compounds were prepared by a one-pot, two-step synthesis, starting from 2-mercaptobenzothiazole and benzyl halides. The potential fungicides were tested against a panel of phytopathogenic fungi, with many of them showing a significant improvement compared to the non-oxidized analogues and the commercial antifungal Captan. The new derivatives 2-((2-chlorobenzyl)sulfonyl)benzo[d]thiazole (4f) and 2-((4-methylbenzyl)sulfonyl)benzo[d]thiazole (4k) presented remarkable properties, being able to inhibit the growth of two resistant moulds (Aspergillus fumigatus and Aspergillus ustus). Both 4f and 4k could be classified as broad-spectrum fungicides, emerging as possible candidates for the control of these moulds, which have negative impact in food production.