1,2,5-Oxadiazole N-oxide derivatives as potential anti-cancer agents: Synthesis and biological evaluation. Part IV

dc.creatorBoiani, Mariana
dc.creatorCerecetto, Hugo
dc.creatorGonzález, Mercedes
dc.creatorRisso, Mariela
dc.creatorOlea Azar, Claudio
dc.creatorPiro, Oscar Enrique
dc.creatorCastellano, Eduardo E.
dc.creatorLópez De Ceráin, Adela
dc.creatorEzpeleta, Olga
dc.creatorMonge Vega, Antonio
dc.date2001-12
dc.identifierhttp://hdl.handle.net/11336/99157
dc.identifierBoiani, Mariana; Cerecetto, Hugo; González, Mercedes; Risso, Mariela; Olea Azar, Claudio; et al.; 1,2,5-Oxadiazole N-oxide derivatives as potential anti-cancer agents: Synthesis and biological evaluation. Part IV; Elsevier France-editions Scientifiques Medicales Elsevier; European Journal of Medical Chemistry; 36; 10; 12-2001; 771-782
dc.identifier0223-5234
dc.identifierCONICET Digital
dc.identifierCONICET
dc.descriptionSeveral new 1,2,5-oxadiazole N-oxide derivatives and some deoxygenated analogues were synthesized to be tested as potential selective hypoxic cell cytotoxins. Compounds prepared were designed in order to gain insight into the mechanism of action of this kind of cytotoxin. Compounds were tested in oxia and hypoxia and they proved to be non-selective. 3-Cyano-N2-oxide-4-phenyl-1,2,5-oxadiazole showed the best cytotoxic activity in oxia. The cytotoxicity observed for these derivatives could be explained in terms of the electronic characteristics of the 1,2,5-oxadiazole substituents. Electrochemical and ESR studies were performed on the more cytotoxic derivative. © 2001 Éditions scientifiques et médicales Elsevier SAS.
dc.descriptionFil: Boiani, Mariana. Universidad de la República Facultad de Química; Uruguay
dc.descriptionFil: Cerecetto, Hugo. Universidad de la República Facultad de Química; Uruguay
dc.descriptionFil: González, Mercedes. Universidad de la República Facultad de Química; Uruguay
dc.descriptionFil: Risso, Mariela. Universidad de la República Facultad de Química; Uruguay
dc.descriptionFil: Olea Azar, Claudio. Universidad de Chile; Chile
dc.descriptionFil: Piro, Oscar Enrique. Facultad de Ciencias Exactas, Universidad Nacional de la Plata; Argentina
dc.descriptionFil: Castellano, Eduardo E.. Universidade de Sao Paulo; Brasil
dc.descriptionFil: López De Ceráin, Adela. Universidad de Navarra; España
dc.descriptionFil: Ezpeleta, Olga. Universidad de Navarra; España
dc.descriptionFil: Monge Vega, Antonio. Universidad de Navarra; España
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier France-editions Scientifiques Medicales Elsevier
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.1016/S0223-5234(01)01265-X
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S022352340101265X
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject1,2,5-OXADIAZOLE N-OXIDE
dc.subjectANTI-CANCER AGENTS
dc.subjectSTRUCTURE-ACTIVITY RELATIONSHIPS
dc.subjecthttps://purl.org/becyt/ford/1.3
dc.subjecthttps://purl.org/becyt/ford/1
dc.title1,2,5-Oxadiazole N-oxide derivatives as potential anti-cancer agents: Synthesis and biological evaluation. Part IV
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


Este ítem pertenece a la siguiente institución