info:eu-repo/semantics/article
1,2,5-Oxadiazole N-oxide derivatives as potential anti-cancer agents: Synthesis and biological evaluation. Part IV
Registro en:
Boiani, Mariana; Cerecetto, Hugo; González, Mercedes; Risso, Mariela; Olea Azar, Claudio; et al.; 1,2,5-Oxadiazole N-oxide derivatives as potential anti-cancer agents: Synthesis and biological evaluation. Part IV; Elsevier France-editions Scientifiques Medicales Elsevier; European Journal of Medical Chemistry; 36; 10; 12-2001; 771-782
0223-5234
CONICET Digital
CONICET
Autor
Boiani, Mariana
Cerecetto, Hugo
González, Mercedes
Risso, Mariela
Olea Azar, Claudio
Piro, Oscar Enrique
Castellano, Eduardo E.
López De Ceráin, Adela
Ezpeleta, Olga
Monge Vega, Antonio
Resumen
Several new 1,2,5-oxadiazole N-oxide derivatives and some deoxygenated analogues were synthesized to be tested as potential selective hypoxic cell cytotoxins. Compounds prepared were designed in order to gain insight into the mechanism of action of this kind of cytotoxin. Compounds were tested in oxia and hypoxia and they proved to be non-selective. 3-Cyano-N2-oxide-4-phenyl-1,2,5-oxadiazole showed the best cytotoxic activity in oxia. The cytotoxicity observed for these derivatives could be explained in terms of the electronic characteristics of the 1,2,5-oxadiazole substituents. Electrochemical and ESR studies were performed on the more cytotoxic derivative. © 2001 Éditions scientifiques et médicales Elsevier SAS. Fil: Boiani, Mariana. Universidad de la República Facultad de Química; Uruguay Fil: Cerecetto, Hugo. Universidad de la República Facultad de Química; Uruguay Fil: González, Mercedes. Universidad de la República Facultad de Química; Uruguay Fil: Risso, Mariela. Universidad de la República Facultad de Química; Uruguay Fil: Olea Azar, Claudio. Universidad de Chile; Chile Fil: Piro, Oscar Enrique. Facultad de Ciencias Exactas, Universidad Nacional de la Plata; Argentina Fil: Castellano, Eduardo E.. Universidade de Sao Paulo; Brasil Fil: López De Ceráin, Adela. Universidad de Navarra; España Fil: Ezpeleta, Olga. Universidad de Navarra; España Fil: Monge Vega, Antonio. Universidad de Navarra; España