info:eu-repo/semantics/article
Electrosprayed Chitosan Microcapsules as Delivery Vehicles for Vaginal Phytoformulations
Fecha
2018-12Registro en:
Moreno, María Alejandra; Gómez Mascaraque, Laura Gómez; Arias, Myriam Elizabeth; Zampini, Iris Catiana; Sayago, Jorge Esteban; et al.; Electrosprayed Chitosan Microcapsules as Delivery Vehicles for Vaginal Phytoformulations; Elsevier; Carbohydrate Polymers; 201; 12-2018; 425-437
0144-8617
CONICET Digital
CONICET
Autor
Moreno, María Alejandra
Gómez Mascaraque, Laura Gómez
Arias, Myriam Elizabeth
Zampini, Iris Catiana
Sayago, Jorge Esteban
Ramos, Liudis Leidy Pino
Schmeda Hirschmann, Guillermo
Lopez Rubio, Amparo
Isla, Maria Ines
Resumen
The design of novel delivery systems to treat vaginal fungalinfections is a topic of high interest. Chitosan, being itselfantimicrobial and having good mucoadhesive properties, is an excellentcandidate as a delivery matrix for active compounds. In this work,chitosan microcapsules containing dry extracts of Argentinean medicinalplants with proved biological properties (Larrea divaricata, L.cuneifolia, L. nitida, Zuccagnia punctata and Tetraglochin andina) weredeveloped through electrospraying and compared with conventionally usedtablets containing the same extracts. Total phenolics(spectrophotometry), morphology and particle size (SEM), molecularorganization (FT-IR spectroscopy), water sorption capacity, release ofbioactive compounds (BC) and biological properties were assessed. Theencapsulation process did not degrade the BC, as antioxidant andantifungal capacity remained unchanged. The FT-IR analysis suggestedinteractions via hydrogen bonding or hydrophobic interactions between thechitosan and the extracts, which explained why the microcapsules kept theintegrity in slightly acidic media. Increased solubility of the extractswhen incorporated in the microcapsules was seen in simulated vaginalfluid, potentially increasing the bioavailability of BC in the vaginalenvironment. This work highlights the potential of the chitosan-baseddelivery systems for phytomedicines with antifungal and antioxidantactivity to be used in vulvovaginal candidiasis.