Assessment of solubility and intestinal absorption in vitro of praziquantel in solid dispersions of polyethylene glycol 6000

dc.creatorChaud, Marco Vinicius
dc.creatorPaula, Fábio C.
dc.creatorMoraes, Larissa C.
dc.creatorGoes, Arielly L.
dc.creatorGranato, Márcia M.
dc.creatorJunior, José M.O.
dc.creatorZaparoli, Roney E.
dc.creatorVila, Marta M. D. C.
dc.creatorCorrêa, Eliane M.
dc.date2011
dc.date2012-01-31T03:00:00Z
dc.identifierhttp://sedici.unlp.edu.ar/handle/10915/8394
dc.identifierhttp://www.latamjpharm.org/resumenes/30/10/LAJOP_30_10_1_6.pdf
dc.descriptionThe aim of this study was to investigate the impact of solid dispersions of polyethylene glycol 6000 (PEG 6000), using the co-precipitation method, on the in vitro solubility and intestinal absorption of praziquantel (PZQ). The solubility of PZQ in solid dispersions and physical mixtures was assessed in purified water and TC-199 buffer. The everted intestinal sac model was employed to assess, in vitro, intestinal absorption of PZQ. A significant enhancement in both in vitro solubility and intestinal absorption of PZQ was found in solid dispersions compared to pure PZQ and physical mixtures. This positive series of preliminary results showed that solid dispersion of PEG 6000 is a valuable strategy for increasing bioavailability of PZQ and could also prove useful for other poorly water-soluble drugs.
dc.descriptionColegio de Farmacéuticos de la Provincia de Buenos Aires
dc.formatapplication/pdf
dc.format1910-1915
dc.languageen
dc.relationLatin American Journal of Pharmacy
dc.relationvol. 30, no. 10
dc.subjectFarmacia
dc.titleAssessment of solubility and intestinal absorption in vitro of praziquantel in solid dispersions of polyethylene glycol 6000
dc.typeArticulo
dc.typeArticulo


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