Articulo
Time-dependent and concentration -dependent upregulation of carbamazepine efflux transporter: a preliminary assessment from salivary drug monitoring
Autor
Maldonado, Cecilia
Fagiolino, Pietro
Vázquez, Marta
Eiraldi, Rosa
Alvariza, Silvana
Bentancur, Camilo
Álvarez, Pablo
Institución
Resumen
The aim of the present study was to detect efflux transporter induction at salivary glands. Six healthy volunteers were involved. On the first day subjects received a single carbamazepine (CBZ) dose of 400 mg. Couples of salivary samples (first and second fraction, S1 and S2) were collected throughout time after dosing. The following 6 days subjects received 200 mg every twelve hours, and morning pre-dose samples were collected. Colegio de Farmacéuticos de la Provincia de Buenos Aires