Synthesis, characterization and evaluation of the effect of chemical modification of chitosan on drug release

dc.creator	Aloorkar, Nagesh H.
dc.creator	Bhatia, Manish S.
dc.date	2011
dc.date	2011-06-21T03:00:00Z
dc.identifier	http://sedici.unlp.edu.ar/handle/10915/8231
dc.identifier	http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_1_7.pdf
dc.description	A novel polymer, chemically modified chitosan was synthesized by reacting with hydrochloride salt of 2-aminoethanoyl chloride. Formation of novel chemically modified chitosan was confirmed by FTIR and NMR spectroscopy and by thermal (DSC) and elemental analysis. Acute oral toxicity study was performed on modified chitosan to check its safety. Ibuprofen, paracetamol and diclofenac sodium tablets were compressed on a single punch tablet machine using the weight granulation method. The drug release was found to be delayed from the formulations containing chemically modified chitosan. Thus, it could be concluded that the change in the hydrophilic balance and the resultant change in the modulation of swelling of the polymer may retard the drug release from polymer matrices.
dc.description	Colegio de Farmacéuticos de la Provincia de Buenos Aires
dc.format	application/pdf
dc.format	882-889
dc.language	en
dc.relation	Latin American Journal of Pharmacy
dc.relation	vol. 30, no. 5
dc.subject	Farmacia
dc.title	Synthesis, characterization and evaluation of the effect of chemical modification of chitosan on drug release
dc.type	Articulo
dc.type	Articulo