Articulo
Influence of process parameters on nimesulide-loaded Poly(D,L-lactide-co-glycolide) microcapsules
Autor
Khan, Shujaat A.
Ahmad, Mahmood
Murtaza, Ghulam
Aamir, Muhammad N.
Rasool, Fatima
Raees, Muhammad A.
Institución
Resumen
Nimesulide was formulated as sustained release microcapsules using biodegradable polymer
Poly(D,L-lactide-co-glycolide) (PLGA) as the release material by non-solvent addition coacervation
method. The prepared microcapsules were evaluated for physico-chemical properties i.e. size analysis,
morphology, micromeritics, drug content, encapsulation efficiency and drug release characteristics. All
microcapsules obtained were discrete, large, free flowing and spherical in shape. The maximum encapsulation
efficiency of nimesulide was up to 81.02 ± 2.10 %. Nimesulide release from microcapsules followed
Higuchi model. Slow release of nimesulide from PLGA microcapsules over 12 h was observed. Colegio de Farmacéuticos de la Provincia de Buenos Aires