Articulo
Comparison of the antioxidant effects of lipid extracts of Roystonea regia (D-004) and saw palmetto on blood oxidative variables of healthy men
Autor
Rodriguez, Iván
Molina, Vivian
Más, Rosa
Illnait, José
Oyarzábal, Ambar
Mendoza, Sarahí
Fernández, Lilia
Fernández, Julio
Gámez, Rafael
Mesa, Meylis
Jiménez, Sonia
Borrero, Lisete
Cruz, Yadira
Pérez, Yohani
Institución
Resumen
D-004, a lipid extract of Roystonea regia fruits that prevents testosterone-induced prostate hyperplasia in rodents, and saw palmetto (SP) lipid extract, used to treat benign prostate hyperplasia, have been shown antioxidant effects. This randomized, double-blind study compared their antioxidant effects in forty healthy men randomised to D-004 or SP (320 mg/day) capsules for 8 weeks. D-004 significantly (p < 0.001) reduced plasma malondialdehyde (MDA) (32.7 %), sulphydril groups (SH-G) (24.6 %) and (p < 0.01) total hydroxyperoxides (TOH) (26.5 %) values and increased (p < 0.001) total antioxidant status (TAS) (44.1 %) and catalase (CAT) (100.0 %) activity. Treatment with SP lowered (p < 0.001) MDA (26.6 %), SH-G (24.1 %), (p < 0.01) TOH (26.3 %) values, and raised (p < 0.001) TAS (57.4 %) and (p < 0.01) CAT (85.7 %) activity. Both treatments were similarly effective and well tolerated. Concluding, D- 004 and SP (320 mg/day) for 8 weeks similarly reduced plasma lipid peroxidation (MDA, TOH) and protein oxidation (SH-G) markers, increased TAS and CAT activity and were well tolerated in healthy men. Colegio de Farmacéuticos de la Provincia de Buenos Aires