| dc.creator | Terroso, Thatiana | |
| dc.creator | Külkamp, Irene C. | |
| dc.creator | Jornada, Denise S. | |
| dc.creator | Pohlmann, Adriana Raffin | |
| dc.creator | Guterres, Sílvia Stanisçuaski | |
| dc.date | 2010-02-01T03:00:00Z | |
| dc.date | 2009 | |
| dc.date.accessioned | 2017-03-08T20:12:58Z | |
| dc.date.available | 2017-03-08T20:12:58Z | |
| dc.identifier | http://hdl.handle.net/10915/7841 | |
| dc.identifier | http://www.latamjpharm.org/trabajos/28/6/LAJOP_28_6_1_3_PNB636I209.pdf | |
| dc.identifier | http://sedici.unlp.edu.ar/handle/10915/7841 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/429908 | |
| dc.description | Nanocapsule suspensions containing coenzyme Q10 were prepared by interfacial deposition. The nanocapsules showed characteristics compatible with dermal application: slightly acid pH, drug content close to 100%, particle size between 213 and 248 nm with low polydispersity and negative zeta potential. Three cosmetic formulations for skin application were developed, one with the free-coenzyme Q10, a second with a suspension of coenzyme Q10-loaded nanocapsules and a third containing dried coenzyme Q10-loaded nanocapsules. The dried nanocapsules were obtained by spray-drying of the suspension. No significant differences in the diameters of the particles after their incorporation in the semi-solid formulations were observed in comparison with those of nanocapsules in the aqueous suspension. The rheological characterization showed that the formulations containing coenzyme Q10-loaded nanocapsules had a pseudoplastic flow, while the formulation containing free-coenzyme Q10 had a yield-pseudoplastic flow. The semi-solid formulations containing coenzyme Q10-loaded nanocapsules suspension or powder of nanocapsules of coenzyme Q10 redispersed in water are promising cosmetic formulations for topical application. | |
| dc.language | en | |
| dc.relation | Latin American Journal of Pharmacy | |
| dc.relation | vol. 28, no. 6 | |
| dc.subject | reología; coenzima Q10 | |
| dc.subject | coenzyme Q10; rheological characterization; semi-solid formulations | |
| dc.subject | Farmacia | |
| dc.subject | Nanocápsulas | |
| dc.subject | Farmacología | |
| dc.title | Development of semi-solid cosmetic formulations containing coenzyme Q10-loaded nanocapsules | |
| dc.type | Artículos de revistas | |
| dc.type | Artículos de revistas | |
