Preparation and evaluation of W/O/W multiple emulsion containing naltrexone hydrochloride: a pilot study

dc.creatorOliveira, Bérgson F.
dc.creatorFerreira, Ana E.R.
dc.creatorFialho, Sílvia L.
dc.creatorSilva Cunha Júnior, Armando da
dc.date2009-08-06T03:00:00Z
dc.date2009
dc.date.accessioned2017-03-08T20:12:37Z
dc.date.available2017-03-08T20:12:37Z
dc.identifierhttp://hdl.handle.net/10915/7776
dc.identifierhttp://www.latamjpharm.org/trabajos/28/3/LAJOP_28_3_1_12_HFO4TCESP6.pdf
dc.identifierhttp://sedici.unlp.edu.ar/handle/10915/7776
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/429843
dc.descriptionW/O/W multiple emulsions containing naltrexone (NTX) hydrochloride were prepared by a two-step emulsification method at 20 ºC. Characterization of the developed system was evaluated and the release kinetics of the drug was determined. The tissue response to the injection of the multiple emulsion in mice was observed by histological analysis. The entrapment efficiency of NTX hydrochloride in W/O/W multiple emulsion was 97.72 ± 0.8 % and the mean diameter of the multiple globules was 18.6 ± 7.7 μm. The main in vitro drug release mechanism observed for the developed system is supposed to be a swellingbreakdown phenomenon after dilution of the emulsions under hypo-osmotic conditions. Biocompatibility studies showed that the multiple emulsion was well tolerated as no significant toxic reaction was observed. The W/O/W multiple emulsion containing NTX hydrochloride may represent a potential alternative dosage form for the treatment of alcohol dependence.
dc.languageen
dc.relationLatin American Journal of Pharmacy
dc.relationvol. 28, no. 3
dc.subjectalcohol dependence; drug delivery system; naltrexone hydrochloride; W/O/W multiple emulsion
dc.subjectFarmacia
dc.subjectAlcoholismo
dc.subjectEvaluación de drogas
dc.subjectProductos químicos y drogas
dc.titlePreparation and evaluation of W/O/W multiple emulsion containing naltrexone hydrochloride: a pilot study
dc.typeArtículos de revistas
dc.typeArtículos de revistas


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