article
A new n-methoxypyridone from the co-cultivation of Hawaiian endophytic fungi Camporesia sambuci FT1061 and Epicoccum sorghinum FT1062
Autor
Li, Chun-shun
Sarotti, Ariel Marcelo
Yang, Baojun
Turkson, James
Cao, Shugeng
Institución
Resumen
A new N-methoxypyridone analog (1), together with four known compounds, was isolated
from the co-culture of Hawaiian endophytic fungi Camporesia sambuci FT1061 and Epicoccum sorghinum
FT1062. The structure of the new compound was elucidated as 11S-hydroxy-1-methoxyfusaricide (1)
by extensive spectroscopic analysis and comparison with the literature. The absolute configuration of
1 was determined by comparison with the experimental and calculated ECD spectra. The absolute
configuration of compound 3 was investigated and renamed as (+)-epipyridone by comparison of
the optical rotation and CD spectrum with those of 1. The other known compounds were identified
as epicoccarine B (2), D8646-2-6 (4), and iso-D8646-2-6 (5). Compounds 4 and 5 showed modest
inhibitory activity towards pathogenic fungi. Epicoccarine B (2) inhibited A2780 and TK-10 with
an IC50 value of 22 µM. Para citar este articulo: Li, C.; Sarotti, A.M.; Yang, B.; Turkson, J.; Cao, S. A New N-methoxypyridone from the Co-Cultivation of Hawaiian Endophytic Fungi Camporesia sambuci FT1061 and Epicoccum sorghinum FT1062. Molecules 2017, 22, 1166. Fil: Li, Chun-shun. University of Hawai'i at Hilo. Inouye College of Pharmacy. Department of Pharmaceutical Sciences; United States. Fil: Li, Chun-shun. University of Hawaii Cancer Center. Cancer Biology Program; United States. Fil: Sarotti, Ariel Marcelo. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR -CONICET); Argentina. Fil: Yang, Baojun. University of Hawaii Cancer Center. Cancer Biology Program; United States. Fil: Turkson, James. University of Hawaii Cancer Center. Cancer Biology Program; United States. Fil: Cao, Shugeng. University of Hawai'i at Hilo. Inouye College of Pharmacy. Department of Pharmaceutical Sciences; United States. Fil: Cao, Shugeng. University of Hawaii Cancer Center. Cancer Biology Program; United States.