dc.contributorhttps://orcid.org/0000-0002-1995-1696
dc.contributorhttps://orcid.org/0000-0001-6803-925X
dc.contributorhttps://orcid.org/0000-0002-2979-6159
dc.creatorLazalde Ramos, Blanca Patricia
dc.creatorGómez Meda, Belinda Claudia
dc.creatorReyes Estrada, Claudia Araceli
dc.creatorOrtíz García, Yveth Marlene
dc.creatorZamora Pérez, Ana Lourdes
dc.creatorGutiérrez Hernández, Rosalinda
dc.creatorMorales Velazquez, Gabriela
dc.creatorQuirarte Baez, Sol María
dc.creatorZúñiga González, Moisés Zúñiga
dc.date.accessioned2018-06-22T13:33:13Z
dc.date.available2018-06-22T13:33:13Z
dc.date.created2018-06-22T13:33:13Z
dc.date.issued2018-04-03
dc.identifier2379-6294
dc.identifierhttp://hdl.handle.net/20.500.11845/588
dc.identifierhttps://doi.org/10.48779/ab63-h106
dc.description.abstractRosmarinus officinalis is a common household aromatic plant widely used in cosmetic, food and folk medicine. The aim of this study was evaluated rosmarinus total extract (RTE) protective effect on DNA damage induced by cyclophosphamide (CP) and evidence the lack of genotoxicity and cytotoxicity of RTE in peripheral blood erythrocytes of Balb-C mice using the micronucleus assay. To evaluate the DNA protective effect, the dose of 100mg/kg of RTE was used and given orally. Following was the admiration of CP (50mg/kg). To evaluated the lack genotoxic or cytotoxic, three doses (30, 100 and 300mg/kg) of RTE were administered orally. A drop of blood was obtained from the tip of the tail of each mouse 24h for six days. We found no increase of micronucleated erythrocytes (MNE) or micronucleated polychromatic erythrocytes (MNPCE). Nor did polychromatic erythrocytes (PCE) decline in mice treated with one of the three different doses of RTE. RTE extracts were capable of diminished DNA damage caused by CP thus reducing MNE and MNPCE frequencies. The lack of genotoxic and cytotoxic effect of the RTE and reduces the genotoxicity caused by CP, suggest the potential therapeutic usefulness of this plant extract.
dc.languageeng
dc.publisherMedCrave Step into the world of research
dc.relationhttp://medcraveonline.com/MOJT/current-issue
dc.relationgeneralPublic
dc.relationhttp://medcraveonline.com/MOJT/current-issue
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/3.0/us/
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Estados Unidos de América
dc.sourceMOJ Toxicology Vol. 4, Núm. 2, pp. 75-79
dc.titleDNA protective effect of rosmarinus officinalis total extract in mouse peripheral blood
dc.typeinfo:eu-repo/semantics/article


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